Cerva L
Science. 1980 Sep 26;209(4464):1541. doi: 10.1126/science.7433975.
Trimethoprim in a concentration of 4 micrograms per milliter of Bacto-Casitone (Difco) medium inhibits the growth of nonvirulent Naegleria fowleri isolates. The growth of virulent strains is unaffected even with 400 micrograms of the drug per milliliter of medium. Differences in sensitivity constitute the possibility of a simple selection of environmental isolates. The pathogenicity and virulence of Naegleria species may be connected with the metabolism of folic acid.
每毫升细菌酪蛋白胨（Difco）培养基中浓度为4微克的甲氧苄啶可抑制无毒福氏耐格里阿米巴分离株的生长。即使每毫升培养基中含有400微克该药物，有毒菌株的生长也不受影响。敏感性差异构成了简单筛选环境分离株的可能性。耐格里属物种的致病性和毒力可能与叶酸代谢有关。
