[Clinico-pharmacological investigation of an oral form of a depot preparation on silicone resin base with indomethacin as the active ingredient].

Indomethacin depot tablets on the basis of silicon resin were investigated in a clinical pharmacological study including pharmacokinetic data on 20 patients with rheumatoid arthritis. Effects and side-effects of the depot tablet are equal to those of the standard Metindol-capsules. After depot tablets serum indomethacin level is in the therapeutic range for 8--12 hours so that drug administration is reduced to twice daily.