Storch W, Ditscherlein G, Lange E, Lössner J
Z Urol Nephrol. 1980 Mar;73(3):181-90.
12 patients with Wilson's disease were examined by means of renal biopsy. In 9 of these patients a slight (4 patients) or a strong proteinuria (5 patients) appeared during the therapy with D-penicillamine. A biopsy was performed in 3 patients before the beginning of the therapy with D-penicillamine. The patients with severe proteinuria showed the largest immunohistological changes (partly distinct immune complex nephritis with epimembranous IgG- and complement-(C3-) depositions -- electronoptically membranous glomerulonephritis. In rebiopsy after a stoppage of the medicament of 1 year only a slight tendency to improvement was to be recognized.
对12例威尔逊病患者进行了肾活检。其中9例患者在使用青霉胺治疗期间出现了轻度蛋白尿（4例）或重度蛋白尿（5例）。在开始使用青霉胺治疗前，对3例患者进行了活检。重度蛋白尿患者的免疫组织学变化最为明显（部分为明显的免疫复合物性肾炎，伴有膜上皮IgG和补体（C3）沉积——电镜下为膜性肾小球肾炎）。在停药1年后再次活检时，仅发现有轻微的改善趋势。
