Storch W, Berger H
Z Gesamte Inn Med. 1980 Jul 1;35(13):567-70.
18 patients with Wilson's disease with and without proteinuria and 19 test persons without Wilson's disease were examined for a disturbance of the transformation on account of phythemagglutinin, streptolysin-O and several D-penicillamine preparations by means of the lymphocyte transformation test. Also during the therapy with D-penicillamine was no cause for a disturbed transformation of lymphocytes on the mitogen phythemagglutinin. A cell-conditioned immune reaction to D-penicillamine which could be established by means of the lymphocyte transformation test under the conditions chosen seems to be present in patients with Wilson's disease neither in lacking or insignificant nor in pronounced proteinuria. The increased transformation rates to streptolysin-O in Wilson's disease need confirmation in a larger number of patients. Like the increased spontaneous transformation rates they might refer to an immune-stimulating effect of the D-penicillamine.
对18例患有和未患有蛋白尿的威尔逊氏病患者以及19例未患威尔逊氏病的测试对象，通过淋巴细胞转化试验，检测因植物血凝素、链球菌溶血素 - O和几种青霉胺制剂导致的转化障碍。在使用青霉胺治疗期间，也没有发现有丝分裂原植物血凝素导致淋巴细胞转化障碍的情况。在所选择的条件下，通过淋巴细胞转化试验可以确定，威尔逊氏病患者似乎不存在针对青霉胺的细胞条件免疫反应，无论其是否存在蛋白尿，蛋白尿程度是轻微还是严重。威尔逊氏病患者对链球菌溶血素 - O的转化率增加需要在更多患者中得到证实。与自发转化率增加一样，它们可能归因于青霉胺的免疫刺激作用。
