Andersson A C, Henningsson S
Acta Endocrinol (Copenh). 1980 Oct;95(2):237-43. doi: 10.1530/acta.0.0950237.
In the ovaries of pre-pubertal rats stimulated by human chorionic gonadotrophin (hCG) the temporal changes in cadaverine and putrescine formation were investigated. In addition, the dose-response relationship of hCG and its effect on the diamine formation and the effect of hCG on the content of diamines and polyamines in the ovaries and the urine were studied. The results show that the ovary stimulated by hCG, in addition to putrescine, forms cadaverine at a highly increased rate. The elevated diamine formation was parallelled by an increased content of cadaverine and putrescine in the ovary. Treatment with aminoguanidine elevated the content of cadaverine in the ovary, suggesting that diamine oxidase has a role as a regulator of the intra-ovary level of cadaverine. These results confirm that cadaverine can be synthesized in an inducible manner in mammalian tissues. This is, virtually, the first report of elevated formation of cadaverine in response to an exogenous gonadotrophin.
在人绒毛膜促性腺激素（hCG）刺激的青春期前大鼠卵巢中，研究了尸胺和腐胺形成的时间变化。此外，还研究了hCG的剂量反应关系及其对二胺形成的影响，以及hCG对卵巢和尿液中二胺和多胺含量的影响。结果表明，受hCG刺激的卵巢除了形成腐胺外，还以极高的速率形成尸胺。卵巢中二胺形成的增加与尸胺和腐胺含量的增加平行。用氨基胍处理可提高卵巢中尸胺的含量，这表明二胺氧化酶在调节卵巢内尸胺水平方面发挥作用。这些结果证实，尸胺可以在哺乳动物组织中以诱导方式合成。实际上，这是关于外源性促性腺激素引起尸胺形成增加的首次报道。
