Hetzel W
Acta Neuropathol. 1980;51(1):15-22. doi: 10.1007/BF00688845.
The ependymal lining of the lateral ventricles of the brain of rats, rabbits, and man was investigated at several times after death. In contrast to control material that was fixed by the aldehyde perfusing method, the following post-mortem (p.m.) changes were found: (1) Cytoplasmic protrusions of ependymal cells appear 15 min p.m. They are present up to several hours after death. (2) The formation of these protrusions causes the tufts of cilia to clump together and later to become integrated within the ependymal cell. This may simulate an unciliated surface. (3) Small porelike holes, which are present 15 min p.m. in the ependymal cell membrane, enlarge and in later stages produce a meshwork of fibers instead of a closed ependymal lining. (4) TEM observation shows that ependymal cells are separated from each other very soon after death by intercellular gaps. Cell junctions between ependymal cells resist separation over a longer p.m. period. In animal or human material that is fixed at any time after death, such modifications have to be considered very critically. In human p.m. autopsy material they are mostly the expression of a p.m. alteration.
在大鼠、兔子和人类死后的不同时间，对其大脑侧脑室的室管膜内衬进行了研究。与通过醛灌注法固定的对照材料相比，发现了以下死后（p.m.）变化：（1）室管膜细胞的细胞质突起在死后15分钟出现。它们在死后数小时内一直存在。（2）这些突起的形成导致纤毛簇聚集在一起，随后整合到室管膜细胞内。这可能模拟无纤毛表面。（3）室管膜细胞膜在死后15分钟出现的小孔状孔洞会扩大，在后期形成纤维网络，而不是完整的室管膜内衬。（4）透射电镜观察显示，死后不久室管膜细胞通过细胞间隙彼此分离。室管膜细胞之间在较长的死后时间段内抵抗分离。在死后任何时间固定的动物或人类材料中，必须非常严格地考虑这些改变。在人类死后尸检材料中，它们大多是死后改变的表现。
