营养不良性轴突中的线粒体间分隔结构。

Intermitochondrial septate structures in dystrophic axons.

作者信息

Ramos P L, Wisniewski K, Jervis G A, Wisniewski H M

出版信息

Acta Neuropathol. 1980;52(2):105-9. doi: 10.1007/BF00688007.

Abstract

Intermitochondrial septate structures were found in the dystrophic axons of two cases of infantile neuroaxonal dystrophy. Septate structures were previously seen in some tumors (glioblastomas and Schwannomas) and several organs of vertebrates and invertebrates, but never in human central nervous system (CNS). The structures were studied by transmission and transmission tilt electron microscopy. A proposed model was constructed and X-rayed. Artist's depictions are shown and described. The intermitochondrial septate structures have a periodicity of 120 A which puts them within the range of those structures previously reported. It was found that our structures are not true junctions, but a complex interdigitation of the outer membranes of the involved mitochondria.

摘要

在两例婴儿型神经轴索营养不良患者的营养不良轴突中发现了线粒体间的分隔结构。分隔结构先前在一些肿瘤（胶质母细胞瘤和神经鞘瘤）以及脊椎动物和无脊椎动物的多个器官中可见，但从未在人类中枢神经系统（CNS）中发现过。通过透射电子显微镜和透射倾斜电子显微镜对这些结构进行了研究。构建了一个提议的模型并进行了X射线分析。展示并描述了艺术家的描绘。线粒体间的分隔结构具有120埃的周期性，这使其处于先前报道的那些结构的范围内。研究发现，我们所观察到的结构并非真正的连接，而是相关线粒体的外膜复杂的相互交错。