Persson B, Henning M
Acta Pharmacol Toxicol (Copenh). 1980 Aug;47(2):135-43. doi: 10.1111/j.1600-0773.1980.tb01853.x.
Gamma aminobutyric acid (GABA) and different GABA analogues were examined for their cardiovascular actions and their influence on striatal dopamine (DA) levels and GABA accumulation after aminooxyacetic acid (AOAA). Gamma hydroxybutyric acid (GHBA) and baclofen caused hypertension and tachycardia after systemic as well as intracerebroventricular administration, while the opposite was true for GABA and muscimol. The hypertension after GHBA and baclofen was not reduced by picrotoxin or bicuculline and was not influenced by varying GABA levels by 3-mercaptopropionic acid (3-MPA) or AOAA. GHBA and muscimol but not baclofen reduced GABA accumulation induced by AOAA. Picrotoxin in a subconvulsive dose increased GABA accumulation and antagonized the inhibition after GHBA or muscimol. Bicuculline and a moderate dose of picrotoxin tended to decrease GABA accumulation by themselves and if anything augmented the effects of GHBA and muscimol. GHBA and baclofen but not muscimol in combination with AOAA increased DA levels, which was not prevented by picrotoxin or bicuculline. We conclude that the cardiovascular actions of GHBA and baclofen are probably not mediated by mechanisms identical to those of muscimol or exogenous GABA. In view of the biochemical results their actions would however be compatible with a concept of different GABA receptors.
研究了γ-氨基丁酸（GABA）及不同的GABA类似物的心血管作用，以及它们对氨基氧乙酸（AOAA）处理后纹状体多巴胺（DA）水平和GABA蓄积的影响。γ-羟基丁酸（GHBA）和巴氯芬经全身给药及脑室内给药后可引起高血压和心动过速，而GABA和蝇蕈醇的作用则相反。GHBA和巴氯芬引起的高血压不受印防己毒素或荷包牡丹碱的影响，且不受3-巯基丙酸（3-MPA）或AOAA改变GABA水平的影响。GHBA和蝇蕈醇可降低AOAA诱导的GABA蓄积，但巴氯芬无此作用。亚惊厥剂量的印防己毒素可增加GABA蓄积，并拮抗GHBA或蝇蕈醇后的抑制作用。荷包牡丹碱和中等剂量的印防己毒素本身倾向于降低GABA蓄积，且在一定程度上增强了GHBA和蝇蕈醇的作用。GHBA和巴氯芬与AOAA联合使用可增加DA水平，而印防己毒素或荷包牡丹碱不能阻止这一作用。我们得出结论，GHBA和巴氯芬的心血管作用可能不是由与蝇蕈醇或外源性GABA相同的机制介导的。鉴于生化结果，它们的作用与不同GABA受体的概念是相符的。
