Borsini F, Evangelista S, Meli A
Eur J Pharmacol. 1986 Feb 18;121(2):265-8. doi: 10.1016/0014-2999(86)90498-x.
Aminooxyacetic acid (AOAA, 25 mg/kg i.p.), muscimol (2 mg/kg i.p.) and 4,5,6,7-tetrahydroisooxazol-[4,5-c]-pyridin-3-ol (THIP, 5 and 10 mg/kg s.c.), but not baclofen (10 mg/kg i.p.) administered three times (24, 5 and 1 h before the test) decreased the immobility time of rats in the behavioral 'despair' test. At these doses, AOAA, muscimol and THIP reduced motor activity. Muscimol (2 mg/kg) and THIP (5 and 10 mg/kg) exerted the antiimmobility effect even after single dosing 1 h before the test. Picrotoxin (1 and 2 mg/kg i.p.), but not bicuculline (2 mg/kg i.p.), prevented the effect of both muscimol and THIP in the behavioral 'despair' test.
氨氧乙酸（AOAA，腹腔注射25毫克/千克）、蝇蕈醇（腹腔注射2毫克/千克）和4,5,6,7-四氢异恶唑并[4,5-c]吡啶-3-醇（THIP，皮下注射5和10毫克/千克），而非巴氯芬（腹腔注射10毫克/千克），在行为“绝望”试验前三次给药（分别在试验前24、5和1小时），可减少大鼠的不动时间。在这些剂量下，AOAA、蝇蕈醇和THIP会降低运动活性。即使在试验前1小时单次给药，蝇蕈醇（2毫克/千克）和THIP（5和10毫克/千克）仍具有抗不动作用。印防己毒素（腹腔注射1和2毫克/千克），而非荷包牡丹碱（腹腔注射2毫克/千克），可在行为“绝望”试验中阻止蝇蕈醇和THIP的作用。
