Tfelt-Hansen P, Eickhoff J H, Olesen J
Acta Pharmacol Toxicol (Copenh). 1980 Aug;47(2):151-6. doi: 10.1111/j.1600-0773.1980.tb01855.x.
Ergotamine tartrate (0.5 mg/70 kg) was given intravenously to 17 migraine patients. Arm, finger, ankle and big toe systolic blood pressures were measured with strain gauge technique for up to 4 hours and again after 22 hours. Systolic arm blood pressure increased transiently (duration less than 3 hours). Peripheral systolic blood pressures decreased in all patients (for toes a few to 55 mmHg) and at 22 hours well sustained decreases were still found. Further 10 migraine patients received 2-4 mg ergotamine tartrate as suppositories and peripheral systolic blood pressures were measured for 3 days. A decrease in peripheral systolic blood pressure was found after 24 hours but had disappeared after 48 hours. Contrary to common belief the present study investigating the effect of ergotamine directly on arteries has shown a long duration of its vasoconstrictory effect. Thus the effect of a single dose of ergotamine on the arteries should be followed for days.
将酒石酸麦角胺（0.5毫克/70千克）静脉注射给17名偏头痛患者。采用应变计技术测量手臂、手指、脚踝和大脚趾的收缩压，测量时间长达4小时，并在22小时后再次测量。手臂收缩压短暂升高（持续时间少于3小时）。所有患者的外周收缩压均下降（脚趾下降幅度为几毫米汞柱至55毫米汞柱），在22小时时仍发现有持续的下降。另外10名偏头痛患者接受2 - 4毫克酒石酸麦角胺栓剂治疗，并测量外周收缩压3天。24小时后发现外周收缩压下降，但48小时后消失。与普遍看法相反，本研究调查酒石酸麦角胺对动脉的直接作用，显示出其血管收缩作用持续时间较长。因此，单次剂量酒石酸麦角胺对动脉的作用应持续观察数天。
