Tfelt-Hansen P, Olesen J
Acta Pharmacol Toxicol (Copenh). 1981 Jan;48(1):69-72. doi: 10.1111/j.1600-0773.1981.tb01590.x.
Ten former ergotamine abusers were given ergotamine tartrate 0.5 mg/70 kg intravenously. The arterial response was followed by measuring systolic blood pressures with strain gauge on arm, fingers, ankles and toes. Distal systolic blood pressures were significantly reduced relative to the arm level for 22 hours. The arterial response in these 10 patients was compared to the response in 17 migraine patients tested with the same technique. No differences were found. We conclude that hypersensitivity or tolerance to ergotamine tartrate is not observed in previous ergotamine abusers. Previous abuse is a relative contraindication to the use of ergotamine. But if ergotamine is the only effective drug, normal dosage can be used according to the present results.
对10名曾滥用麦角胺的患者静脉注射酒石酸麦角胺，剂量为0.5毫克/70千克。通过用应变仪测量手臂、手指、脚踝和脚趾处的收缩压来跟踪动脉反应。相对于手臂水平，远端收缩压在22小时内显著降低。将这10名患者的动脉反应与17名采用相同技术测试的偏头痛患者的反应进行比较，未发现差异。我们得出结论，在既往麦角胺滥用者中未观察到对酒石酸麦角胺的超敏反应或耐受性。既往滥用是使用麦角胺的相对禁忌证。但如果麦角胺是唯一有效的药物，根据目前的结果可以使用正常剂量。
