Ross J W, Fraser M D, Moore T D
Am J Clin Pathol. 1980 Oct;74(4 Suppl):521-30.
Relationships of concentration and coefficients of variation for 31 clinical laboratory analytes are described. Estimated mean regression curves and standard deviations of individual laboratory coefficients of variation about the mean regression are calculated. Most analytes showed a significant relationship between concentration and coefficient of variation. State-of-the-art precision is compared with medical goals. The relationship of precision performance standards to the state-of-the-art precision, statistical outliers, and laboratory error is discussed. Statistically significant trends of improving analytic precision are observed for most analytes in both manual and automated methods.
本文描述了31种临床实验室分析物的浓度与变异系数之间的关系。计算了估计的平均回归曲线以及各个实验室变异系数相对于平均回归的标准差。大多数分析物的浓度与变异系数之间存在显著关系。将当前的精密度与医学目标进行了比较。讨论了精密度性能标准与当前精密度、统计异常值和实验室误差之间的关系。在手动和自动方法中，大多数分析物均观察到分析精密度提高的具有统计学意义的趋势。
