Ross J W, Fraser M D
Am J Clin Pathol. 1977 Jul;68(1 Suppl):130-41.
Relationships of concentration and coefficient of variation for 14 clinical chemistry analytes are described. Estimated mean regression curves and standard deviations of individual laboratory coefficients of variation about the mean regression are calculated. Two analytes, calcium and sodium, showed no relationship of concentration to precision. Twelve analytes showed significant relations between concentration and coefficient of variation. State-of-the-art precision is compared with medical goals. The average coefficient of variation for one analyte, calcium, fails to meet medical goals for automated or manual methods. Average precisions for 13 analytes meet medical goals. The distribution of individual laboratory precision above average state-of-the-art figures is discussed. The proportions of laboratories failing to meet medical goals are large for sodium, chloride and glucose, in addition to calcium.
描述了14种临床化学分析物的浓度与变异系数之间的关系。计算了估计的平均回归曲线以及各个实验室变异系数相对于平均回归的标准差。钙和钠这两种分析物的浓度与精密度之间没有关系。12种分析物的浓度与变异系数之间存在显著关系。将当前的精密度与医学目标进行了比较。一种分析物钙的平均变异系数未达到自动化或手工方法的医学目标。13种分析物的平均精密度达到了医学目标。讨论了高于当前平均水平的各个实验室精密度的分布情况。除了钙之外，钠、氯和葡萄糖未达到医学目标的实验室比例也很大。
