Comparison of human and sheep chorion laeve permeability to glucose, beta-hydroxybutyrate, and glycerol.

Significant permeability of in vitro human chorion laeve to glucose, glycerol, and beta-hydroxybutyrate (betaOH butyrate) and in vitro sheep chorion leave to glycerol and betaOH butyrate was measured. Diffusion across these tissues of glycerol and betaOH butyrate corresponded to the relative molecular size, charge, and lipid solubility of these compounds. The simple diffusion of glucose across human chorion leave was somewhat reduced by metabolic conversion of this compound during the transfer process. Demonstration of in vitro human placental tissue permeability to ketoacids and glycerol suggests that these compounds cross to the fetus when elevated in the maternal diabetic state.