Huikeshoven F, Coleman T G, Jongsma H W
Am J Physiol. 1980 Sep;239(3):R317-25. doi: 10.1152/ajpregu.1980.239.3.R317.
A mathematical model was developed to study and to interpret the results of different experiments undertaken in the field of fetal cardiovascular physiology. This model consists of a total of six peripheral blood compartments and a detailed description of the heart. The unique characteristics of the fetal circulation, particularly the ductus arteriosus, the foramen ovale, and the placenta are incorporated into this model. No control mechanisms are incorporated. The model was validated by simulating several previously described experiments. First, the performance of the individual ventricles was measured. The results indicate that, in the normal physiological situation, the right ventricle is working near the upper limits of its function while the left ventricle works below its limits. Second, the circulatory system was stressed by increasing the blood volume and the results show a shift from right to left in the relative contributions of each ventricle to the total cardiac output. Finally, effects of clamping the several blood vessels of the umbilical cord were studied.
开发了一个数学模型，用于研究和解释在胎儿心血管生理学领域进行的不同实验的结果。该模型总共由六个外周血腔室和对心脏的详细描述组成。胎儿循环的独特特征，特别是动脉导管、卵圆孔和胎盘，被纳入该模型。未纳入控制机制。通过模拟几个先前描述的实验对该模型进行了验证。首先，测量了各个心室的性能。结果表明，在正常生理情况下，右心室在其功能上限附近工作，而左心室在其下限以下工作。其次，通过增加血容量对循环系统施加压力，结果显示每个心室对总心输出量的相对贡献从右向左转移。最后，研究了夹闭脐带几根血管的效果。
