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用溴代三苯乙烯抑制小鼠乳腺的发育。

Inhibition of the development of the mammary glands of mice with a bromotriphenylethylene.

作者信息

Rendon A M, Rudali G, Guggiari M

出版信息

Biomedicine. 1978 Nov;29(8):276-9.

PMID:743562
Abstract

Administration of a bromotriphenylethylene to C3H/f(XVII/G) female mice implanted with a pituitary under the kidney capsule produces with high doses (200 mg/kg or 20 mg/kg of diet) a strong inhibition of the development of the mammary glands. With a low dose (2 mg/kg) no inhibition was observed. In mice which received the high doses no hyperplastic alveolar nodules were observed. The activity of the compound is more pronounced after 50 days than after 25 days.

摘要

给肾囊下植入垂体的C3H/f(XVII/G)雌性小鼠施用溴代三苯乙烯,高剂量(200毫克/千克或饮食中20毫克/千克)会强烈抑制乳腺发育。低剂量(2毫克/千克)时未观察到抑制作用。接受高剂量的小鼠未观察到增生性肺泡结节。该化合物在50天后的活性比25天后更明显。

相似文献

1
Inhibition of the development of the mammary glands of mice with a bromotriphenylethylene.用溴代三苯乙烯抑制小鼠乳腺的发育。
Biomedicine. 1978 Nov;29(8):276-9.
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[Inhibition of mammary carcinogenesis of C3H/f mice with broparestrol].[溴苯丙炔醇对C3H/f小鼠乳腺癌发生的抑制作用]
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