Van Putten T, May P R, Wilkins J N
Am J Psychiatry. 1980 Nov;137(11):1446-8. doi: 10.1176/ajp.137.11.1446.
Akinesia, a common side effect of antipsychotic drugs, often goes unrecognized by physician and patient. Akinetic apathy and lack of spontaneity can be mistaken for the negative symptoms of schizophrenia and add to the well-known social and emotional disability of schizophrenic patients on maintenance therapy. The authors attempted to identify a measure that might distinguish between akinesia and the negative symptoms of schizophrenia but found no relationship between plasma and saliva chlorpromazine levels or prolactin levels and akinesia. The fact that all of the akinetic but only 31% of the nonakinetic patients rated themselves as drowsy 12 hours after their bedtime dose indicates that drowsiness is a fairly accurate correlate of akinesia.
运动不能是抗精神病药物的常见副作用，常常未被医生和患者认识到。运动不能性淡漠和缺乏自发性可能被误诊为精神分裂症的阴性症状，并加重精神分裂症患者在维持治疗中众所周知的社会和情感障碍。作者试图找到一种能够区分运动不能和精神分裂症阴性症状的方法，但发现血浆和唾液中氯丙嗪水平或催乳素水平与运动不能之间没有关系。所有出现运动不能的患者中，有12小时在睡前服药后将自己评为困倦，而在无运动不能的患者中这一比例仅为31%，这一事实表明困倦是运动不能的一个相当准确的相关指标。
