Mills S E, Cooper P H, Fechner R E
Am J Surg Pathol. 1980 Oct;4(5):470-9.
Pyogenic granuloma (PG) has a diagnostic, lobular arrangement of capillaries at its base. The lobules consist of discrete clusters of endothelial cells, and the lumina vary from indistinct to prominent. The superficial portions of the lesion may undergo secondary, nonspecific changes including stromal edema, capillary dilation, inflammation, and a granulation tissue reaction. PG has often been equated with these inflammatory changes but objective diagnostic criteria have not been presented. To avoid confusion and focus on the intrinsic nature of PG we suggest the accurate, descriptive term, lobular capillary hemangioma (LCH). A review of 639 vascular lesions of the oral cavity and upper respiratory tract yielded 73 cases with the characteristic features of LCH. The lip was the most common site (38%), followed by the nose (29%), oral mucosa (18%), and tongue (15%). LCH usually presents as a spontaneous, painless, bleeding mass. There is a predilection for males less than 18 years old, females in the reproductive years, and an equal sex distribution beyond 40 years of age. No examples of LCH were found in 68 vascular lesions from the larynx or trachea.
化脓性肉芽肿（PG）在其底部具有诊断性的小叶状毛细血管排列。小叶由离散的内皮细胞簇组成，管腔从不清楚到明显不等。病变的浅表部分可能会发生继发性非特异性改变，包括间质水肿、毛细血管扩张、炎症和肉芽组织反应。PG常与这些炎症变化等同，但尚未提出客观的诊断标准。为避免混淆并关注PG的内在本质，我们建议使用准确的描述性术语“小叶状毛细血管瘤（LCH）”。对639例口腔和上呼吸道血管病变的回顾发现了73例具有LCH特征的病例。唇部是最常见的部位（38%），其次是鼻部（29%）、口腔黏膜（18%）和舌部（15%）。LCH通常表现为自发的、无痛的出血性肿块。LCH好发于18岁以下男性、育龄期女性，40岁以上性别分布均等。在68例来自喉或气管的血管病变中未发现LCH病例。
