Callas G, Adkisson V T
Anat Rec. 1980 Jul;197(3):331-7. doi: 10.1002/ar.1091970307.
Pressure-volume characteristics of whole lungs were measured in euthyroid rats and in rats fed 0.4% desiccated thyroid for eight weeks. The lungs were degassed by incising the diaphragm after the animals had breathed 100% oxygen for ten minutes. The pressure-volume characteristics were measured by inflating and deflating the lungs at a rate of 3.5 cc/min. Total lung capacity (TLC) was considered to be that volume of air required to produce a transpulmonary pressure of 30 cm H2O. At TLC there was 35% greater lung volume in the thyroid-treated animals than in their littermate controls. Similar results were observed in saline-filled lungs. Alveolar surface are (Sa) increased from 0.28m2 in the lungs of control animals to 0.75m2 in lungs of thyroid-treated animals. There was an 85% increase in the alveolar surface density (SVa) in the thyroid-treated animals. These results, obtained by morphometric analysis, suggest that greater lung volume in the thyroid-treated animals resulted from alveolar hyperplasia or "partitioning."
在甲状腺功能正常的大鼠以及喂食0.4%干燥甲状腺素八周的大鼠中测量了全肺的压力-容积特性。在动物吸入100%氧气十分钟后，通过切开膈肌使肺排气。以3.5毫升/分钟的速率对肺进行充气和放气来测量压力-容积特性。总肺容量（TLC）被认为是产生30厘米水柱跨肺压所需的空气体积。在接受甲状腺治疗的动物中，TLC时的肺容积比其同窝对照动物大35%。在充满生理盐水的肺中也观察到了类似结果。肺泡表面积（Sa）从对照动物肺中的0.28平方米增加到接受甲状腺治疗动物肺中的0.75平方米。接受甲状腺治疗的动物肺泡表面密度（SVa）增加了85%。通过形态计量分析获得的这些结果表明，接受甲状腺治疗的动物肺容积增大是由肺泡增生或“分隔”所致。
