Brunette J R, Lafond G
Can J Ophthalmol. 1978 Oct;13(4):269-72.
We studied tapeto-retinal degeneration in the offspring of Royal College of Surgeons (RCS) and Wistar albino rats. Normal ERG values vary according to skin pigmentation: thresholds and implicit times are different. We believe the best experimental material is to be found in the affected pigmented offspring. Evolution of the degeneration over more than 9 months has been observed before extinction and the expressivity of the disease varies from one individual to another. This animal model closely resembles the ERG findings observed clinically in certain pigmentary degenerations of the retina.
我们研究了皇家外科学院（RCS）大鼠和Wistar白化大鼠后代的视网膜色素上皮变性。正常视网膜电图（ERG）值因皮肤色素沉着而异：阈值和隐含时间不同。我们认为，最佳的实验材料是患病的有色后代。在灭绝前已观察到超过9个月的变性演变，并且疾病的表现度因个体而异。这种动物模型与临床上在某些视网膜色素性变性中观察到的ERG结果非常相似。
