Brunette J R, Lafond G
Can J Ophthalmol. 1978 Oct;13(4):265-8.
When Royal College of Surgeons (RCS) rats are bred with Wistar albinos the offspring are deeply pigmented and have normally functioning retinas. From this second generation, various breeding possibilities exist. In the course of successive cross-breedings one can obtain albinos, tan striped (RCS type) or pigmented animals, any one of which may be normal, carrier or affected. The skin pigmentation trait and that of retinal degeneration are independently inherited and follow autosomal recessive Mendelian laws. However normals for ERG studies vary with skin pigmentation. It is suggested that only one group should be chosen and preferably the pigmented variety.
当皇家外科学院（RCS）大鼠与白化Wistar大鼠杂交时，后代色素沉着很深且视网膜功能正常。从第二代开始，存在多种繁殖可能性。在连续杂交过程中，可以获得白化鼠、棕条纹（RCS型）或有色素的动物，其中任何一种都可能是正常的、携带者或患病的。皮肤色素沉着特征和视网膜变性特征是独立遗传的，遵循常染色体隐性孟德尔定律。然而，用于视网膜电图（ERG）研究的正常动物因皮肤色素沉着而有所不同。建议只选择一组，最好是有色素的品种。
