Pederson J A, Matter B J, Czerwinski A W, Llach F
Ann Intern Med. 1980 Sep;93(3):446-8. doi: 10.7326/0003-4819-93-3-446.
The effect of oral charcoal on idiopathic generalized pruritus in 11 stable patients undergoing maintenance hemodialysis was compared to that of placebo dextrose in a controlled, double-blind, cross-over study. Contrasted to placebo, charcoal, 6 g daily for 8 weeks, relieved pruritus subjectively in all but one patient (P = 0.01). Symptomatic relief from pruritus coincided with objective resolutions of active, scratch-induced skin lesions (P = 0.03). No significant alterations were noted in the serum concentrations of standard laboratory variables, including lipids, alkaline phosphatase, phosphorus, or calcium, during treatment with either charcoal or placebo. No adverse effects from the charcoal were noted during the study.
在一项对照、双盲、交叉研究中，比较了口服活性炭对11例维持性血液透析稳定患者特发性全身性瘙痒的影响与安慰剂葡萄糖的效果。与安慰剂相比，活性炭每日6克，持续8周，除1例患者外，所有患者的瘙痒主观上均得到缓解（P = 0.01）。瘙痒症状的缓解与活动性、搔抓引起的皮肤损伤的客观消退相一致（P = 0.03）。在用活性炭或安慰剂治疗期间，标准实验室指标（包括血脂、碱性磷酸酶、磷或钙）的血清浓度未发现明显变化。研究期间未发现活性炭有不良反应。
