Giovannetti S, Barsotti G, Cupisti A, Dani L, Bandini S, Angelini D, Antonelli A, Salvadori M, Urti D A
Institute of Clinical Medicine I, University of Pisa, Italy.
Nephron. 1995;70(2):193-6. doi: 10.1159/000188582.
Twenty-three chronic uremic patients on maintenance hemodialysis and suffering from severe pruritus were treated with activated powdered charcoal (6 g daily p.o.). In 10 patients pruritus disappeared completely, and in 10 other patients a partial effect was observed. The favorable results persisted for several weeks after discontinuation of the treatment. Only 3 cases were totally unresponsive. No relevant undesirable side effects were observed with the exception of 1 case who showed treatment intolerance. It is concluded that activated charcoal per os is a safe, effective, and low-cost therapy for patients with uremic pruritus, but its mechanism of action is unknown.
23例维持性血液透析的慢性尿毒症患者，伴有严重瘙痒，接受活性粉末状活性炭治疗（每日口服6克）。10例患者瘙痒完全消失，另外10例患者观察到部分疗效。治疗停止后，良好效果持续了数周。只有3例完全无反应。除1例出现治疗不耐受外，未观察到相关不良副作用。结论是，口服活性炭对尿毒症瘙痒患者是一种安全、有效且低成本的治疗方法，但其作用机制尚不清楚。
