Van Loon G R, De Souza E B, Kim C
Can J Physiol Pharmacol. 1978 Dec;56(6):1067-71. doi: 10.1139/y78-173.
Repeated intracisternal injections of human beta-endorphin lead to development of tolerance with respect to the catalepsy, analgesia, and hypothermia which are seen following a single injection. The initial injection of beta-endorphin results in increases in the dopamine metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), in neostriatum, as well as increases in the serotonin metabolite, 5-hydroxyindoleacetic acid (5-HIAA), in hypothalamus and brainstem and a decrease in 5-HIAA in hippocampus. In the present study, we report changes in metabolism of dopamine and serotonin in specific brain areas during the development of tolerance to beta-endorphin. Thus, the development of tolerance to beta-endorphin with respect to catalepsy, analgesia, and hypothermia may be mediated by development of tolerance to the effects of beta-endorphin on brain dopamine and serotonin release.
多次脑池内注射人β-内啡肽会导致对单次注射后出现的僵住症、镇痛和体温过低产生耐受性。首次注射β-内啡肽会导致新纹状体中多巴胺代谢产物3,4-二羟基苯乙酸（DOPAC）和高香草酸（HVA）增加，以及下丘脑和脑干中血清素代谢产物5-羟吲哚乙酸（5-HIAA）增加，而海马体中的5-HIAA减少。在本研究中，我们报告了在对β-内啡肽产生耐受性的过程中特定脑区多巴胺和血清素代谢的变化。因此，对β-内啡肽在僵住症、镇痛和体温过低方面的耐受性发展可能是由对β-内啡肽影响脑多巴胺和血清素释放的耐受性发展所介导的。
