Hudemann B, Seyfarth M
Arch Geschwulstforsch. 1980;50(2):173-7.
Dinitrofluorobenzene (DNFB) was used to sensitize 156 patients (124 patients with bladder cancer, 32 controls) to test their ability to be immunized with a newly encountered antigen. All control persons had a normal reaction to DNFB. 16.1% of the tumor patients reacted anerg. The reactivity of the cancer patients depended on the tumor stage. Patients with stage T 1 tumors reacted more positive than those with stage T 3 tumors. Unfortunately, these results had only a value for a group of patients and cannot be extrapolated for application to a given patient. Our results suggested that the prognosis of a cancer patient could be depend of the skin reactivity result. DNFB skin testing is a good method for the estimation of immune status in bladder cancer.
二硝基氟苯(DNFB)用于使156例患者(124例膀胱癌患者,32例对照)致敏,以测试他们对新接触抗原的免疫能力。所有对照者对DNFB均有正常反应。16.1%的肿瘤患者反应呈无反应性。癌症患者的反应性取决于肿瘤分期。T1期肿瘤患者的反应比T3期肿瘤患者更呈阳性。不幸的是,这些结果仅对一组患者有价值,不能外推应用于某一特定患者。我们的结果表明,癌症患者的预后可能取决于皮肤反应结果。DNFB皮肤试验是评估膀胱癌免疫状态的一种好方法。