Gorodilova V V, Mandrik E V, Ul'chenko V M
Vopr Onkol. 1982;28(1):23-7.
The study was concerned with a comparison of immune response to antigen obtained from human embryonic intestine in patients with malignant and benign tumors of the breast and ovaries, cancer of the urinary bladder, cases of various inflammatory diseases and healthy controls. Application of this marker in the skin test of time-delayed hypersensitivity reaction provided a means of evaluation of tumor-associated immunological vigor. The results point to the similarity of skin reactions of time-delayed hypersensitivity in cases of mastopathy and early stages of breast cancer. Therefore, human embryonic antigen may be used as an additional criterion of assessment of immunocompetence of patients with precancerous lesions and malignant neoplasms.
该研究旨在比较乳腺癌、卵巢癌、膀胱癌患者、各种炎症性疾病患者以及健康对照者对源自人胚胎肠道的抗原的免疫反应。将这种标志物应用于迟发型超敏反应的皮肤试验,为评估肿瘤相关的免疫活力提供了一种方法。结果表明,乳腺病和乳腺癌早期患者的迟发型超敏反应皮肤反应具有相似性。因此,人胚胎抗原可作为评估癌前病变和恶性肿瘤患者免疫能力的一项附加标准。