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[人类发育孕期的卵泡发生]

[Folliculogenesis in the prenatal period of human development].

作者信息

Kurilo L F

出版信息

Arkh Anat Gistol Embriol. 1980 Aug;79(8):63-9.

PMID:7436751
Abstract

Quantitative analysis of the follicular formation has been performed in ovaries of 97 human embryos and fetuses (6--40-week-old). The first oocytes at the stage of diplotene appear in 11.5--12-week-old fetuses. Primordial follicles are formed around the oocyte as early as the stage of diplotene. Follicles are intensively formed after the 14th--15th week. Single primordial follicles begin to transform into the growing primary ones in 17-week-old fetuses and the process becomes active after the 19th--20th week of the development. As a rule, the oocyte reaches the stage of dictyotene only after the follicle has transformed into the primary one. By the time of birth most of oocytes are enclosed by the primary, and in less number--by the primordial follicles. The number of secondary and tertiary cavitary follicles is small. The formation rate of follicles with binuclear oocytes and that of polyoocytic follicles is stated. The data on quantitative analysis of oocyte degeneration at the stages of diplotene and dictyotene are presented.

摘要

对97例人类胚胎和胎儿(6至40周龄)的卵巢进行了卵泡形成的定量分析。双线期的初级卵母细胞出现在11.5至12周龄的胎儿中。早在双线期阶段,原始卵泡就在卵母细胞周围形成。卵泡在第14至15周后大量形成。单个原始卵泡在17周龄的胎儿中开始转化为生长中的初级卵泡,并且在发育的第19至20周后该过程变得活跃。通常,卵母细胞只有在卵泡转化为初级卵泡后才达到核网期。到出生时,大多数卵母细胞被初级卵泡包围,少数被原始卵泡包围。次级和三级腔卵泡的数量很少。陈述了双核卵母细胞卵泡和多囊卵泡的形成率。给出了双线期和核网期卵母细胞退化定量分析的数据。

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