Adams D B, Merritt G C, Cripps A W
Aust J Exp Biol Med Sci. 1980 Apr;58(2):167-77. doi: 10.1038/icb.1980.17.
A local antibody response occurred in the small intestine when immune sheep were challenged with the enteric nematode parasite, Trichostrongylus colubriformis. Incoming infective larvae stimulated the appearance of increased numbers of IgA-containing lymphocytes in intestinal lymph. There were increases in the populations of IgA- and IgG1-containing plasma cells in the lamina propria. This did not occur in regions of the small intestine distant to the habitat of T. colubriformis. Challenge infection in immune animals increased the titre of anti-T. colubriformis haemagglutinating antibody in serum, intestinal lymph, intestinal fluid and extracts of intestinal mucosa. Although immune intestinal lymph contains anti-T. colubriformis antibody of IgA isotype, which is presumably produced in intestinal lamina propria, it failed to transfer passive immunity against the parasite. This result, however, does not exclude the possibility that IgA-antibody responses are important in protective immunity against T. colubriformis.
当用肠道线虫寄生虫——蛇形毛圆线虫攻击免疫的绵羊时，小肠中发生了局部抗体反应。进入的感染性幼虫刺激肠道淋巴中含IgA淋巴细胞数量增加。固有层中含IgA和IgG1的浆细胞数量增加。这在距离蛇形毛圆线虫栖息地较远的小肠区域并未发生。对免疫动物进行攻击感染会增加血清、肠道淋巴、肠液和肠黏膜提取物中抗蛇形毛圆线虫血凝抗体的滴度。尽管免疫的肠道淋巴含有推测在肠道固有层产生的IgA同种型抗蛇形毛圆线虫抗体，但它未能传递针对该寄生虫的被动免疫力。然而，这一结果并不排除IgA抗体反应在针对蛇形毛圆线虫的保护性免疫中很重要的可能性。
