Doyle P T, Adams N R
Aust Vet J. 1980 Jul;56(7):331-4. doi: 10.1111/j.1751-0813.1980.tb05743.x.
Four Merino wethers were fed ad libitum on a roughage diet comprised of equal parts of chopped lucerne hay and oaten chaff. The sheep received continuous infusions of DL-methionine into the rumen; the daily dose increasing from 0 g (control treatment) up to 30 g in 3 g amounts at weekly intervals. Dry matter intake (DMI) fell below the control level when 24 g/day or more of the amino acid was infused, while plasma free methionine levels increase substantially when 30 g/day was given. There was no effect of DL-methionine supplementation on the bodyweight of the animals. However, when 30 g/day of DL-methionine was infused one animal died and the acute condition of 2 others necessitated their slaughter. Significant lesions included acute nephrosis and haemolytic anaemia, with milder changes in the liver and pancreas. This report indicates that sheep are unlikely to show the kind of chronic methionine toxicity seen in other species.
四只美利奴阉羊自由采食由等量切碎的苜蓿干草和燕麦糠组成的粗饲料日粮。这些羊通过瘤胃持续输注DL-蛋氨酸；每日剂量从0克（对照处理）开始，每周以3克的增量增加至30克。当输注24克/天或更多的氨基酸时，干物质摄入量（DMI）低于对照水平，而当给予30克/天时，血浆游离蛋氨酸水平大幅升高。补充DL-蛋氨酸对动物体重没有影响。然而，当每天输注30克DL-蛋氨酸时，有一只动物死亡，另外两只动物的急性状况使其不得不被屠宰。显著病变包括急性肾病和溶血性贫血，肝脏和胰腺有较轻变化。本报告表明，绵羊不太可能出现其他物种中所见的那种慢性蛋氨酸毒性。
