Eandi M, Ricci Gamalero S
Boll Soc Ital Biol Sper. 1980 Jan 15;56(1):8-14.
The aim of the present work was to verify whether metronidazole can induce experimental polyneuropathy in rats. The animals were divided into 7 groups and metronidazole was administered orally. Groups 1, 2 and 3 were treated for 32 days respectively with 100, 150, 200 mg/kg/day of metronidazole. The other 4 groups received a daily dose of 150 mg/kg and were sacrificed respectively on the 8th, 16th, 24th, 32nd day of metronidazole administration. The presence of polyneuropathy after treatment was evaluated by behavioural tests and by using an "in vitro" preparation of sciatic nerve-trunk of rat. Metronidazole showed no consistent neurotoxic effects.
本研究的目的是验证甲硝唑是否能在大鼠中诱发实验性多发性神经病。将动物分为7组，口服甲硝唑。第1、2和3组分别用100、150、200mg/kg/天的甲硝唑治疗32天。其他4组每天接受150mg/kg的剂量，并在甲硝唑给药的第8、16、24、32天分别处死。治疗后通过行为测试和使用大鼠坐骨神经干的“体外”制剂评估是否存在多发性神经病。甲硝唑未显示出一致的神经毒性作用。
