再探硫喷妥钠的急性耐受性。

Another look at acute tolerance to thiopentone.

作者信息

Toner W, Howard P J, McGowan W A, Dundee J W

出版信息

Br J Anaesth. 1980 Oct;52(10):1005-8. doi: 10.1093/bja/52.10.1005.

DOI:10.1093/bja/52.10.1005

Abstract

The phenomenon of "acute tolerance" to thiopentone was re-examined in 82 subjects with induction doses of 2-15mg kg-1. There was a strong positive correlation between the venous plasma thiopentone concentrations on recovery from anesthesia and the induction dose, expressed as either mg kg-1 or mg m-2. Recovery time was proportionately shorter with larger doses, being directly related to log10 of the plasma concentration at awakening.

摘要

对82名受试者使用2 - 15mg/kg的诱导剂量重新研究了对硫喷妥钠的“急性耐受性”现象。麻醉恢复时静脉血浆硫喷妥钠浓度与诱导剂量之间存在强正相关，诱导剂量以mg/kg或mg/m²表示。剂量越大，恢复时间成比例地越短，恢复时间与苏醒时血浆浓度的log10直接相关。