Russo H, Bressolle F
Pharmacie Saint-Eloi, Centre Hospitalier Universitaire, Montpellier, France.
Clin Pharmacokinet. 1998 Aug;35(2):95-134. doi: 10.2165/00003088-199835020-00002.
Thiopental is an ultra short-acting barbiturate which remains the standard against which other induction agents are judged; it is also indicated for the therapy of brain hypoxic-ischaemia injuries and status epilepticus. Aspects of drug distribution that govern the onset and end of drug effect have been intensively studied to determine which parameters (in patient characteristics, diseases and administration modalities) influence effective dose and concentrations in individual patients. Thiopental has been used as a reference for pharmacokinetic and/or pharmacodynamic models in the study of rapid and short acting effect drugs. In anaesthesiology the pharmacokinetics of thiopental are described as linear; when doses and duration of treatment increase, nonlinear pharmacokinetics occur because of the saturation and/or the induction of the metabolism.
硫喷妥钠是一种超短效巴比妥类药物，仍是用于评判其他诱导药物的标准；它也被用于治疗脑缺氧缺血性损伤和癫痫持续状态。为确定哪些参数（患者特征、疾病和给药方式方面）会影响个体患者的有效剂量和浓度，人们对决定药物作用起效和结束的药物分布方面进行了深入研究。在快速和短效作用药物的研究中，硫喷妥钠一直被用作药代动力学和/或药效学模型的参考。在麻醉学中，硫喷妥钠的药代动力学被描述为呈线性；当治疗剂量和持续时间增加时，由于代谢的饱和和/或诱导作用，会出现非线性药代动力学。
