氧化费德林与普萘洛尔——心绞痛的对照试验。
Oxyfederine and propranolol--a controlled trial in angina pectoris.
作者信息
Whittington J, Raftery E B
出版信息
Br J Clin Pharmacol. 1980 Nov;10(5):439-42. doi: 10.1111/j.1365-2125.1980.tb01785.x.
Abstract
1 A double-blind-crossover randomised trial was performed to compare the effects of oxyfedrine (maximum dose 32 mg three times daily), propranolol (maximum dose 120 mg three times daily) and placebo in 30 patients with chronic stable angina pectoris. Assessment was by means of symptom level, ECG responses to graded exercise and haematological and biochemical investigation. 2 Oxyfedrine and propranolol resulted in similar significant improvements in symptom level (P < 0.05 in both cases), and ST index (propranolol P < 0.02; oxyfedrine P < 0.05). Neither drug produced any significant changes in haematologaical or biochemical investigations and only infrequent minor side effects were noted. 3 These results indicate that oxyfedrine is a safe and well-tolerated drug with an efficacy comparable with that of propranolol in the treatment of patients with angina pectoris.
摘要
- 进行了一项双盲交叉随机试验，以比较奥昔非君（最大剂量为每日3次，每次32毫克）、普萘洛尔（最大剂量为每日3次，每次120毫克）和安慰剂对30例慢性稳定型心绞痛患者的疗效。通过症状水平、分级运动时的心电图反应以及血液学和生化检查进行评估。2. 奥昔非君和普萘洛尔在症状水平上均产生了相似的显著改善（两者均P < 0.05），以及ST段指数（普萘洛尔P < 0.02；奥昔非君P < 0.05）。两种药物在血液学或生化检查中均未产生任何显著变化，仅偶尔出现轻微副作用。3. 这些结果表明，奥昔非君是一种安全且耐受性良好的药物，在治疗心绞痛患者方面其疗效与普萘洛尔相当。
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Oxyfederine and propranolol--a controlled trial in angina pectoris.氧化费德林与普萘洛尔——心绞痛的对照试验。
Br J Clin Pharmacol. 1980 Nov;10(5):439-42. doi: 10.1111/j.1365-2125.1980.tb01785.x.
2
Double-blind crossover clinical trial of oxyfedrine and propranolol in angina pectoris.
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Br J Clin Pharmacol. 1980 Sep;10(3):211-5. doi: 10.1111/j.1365-2125.1980.tb01746.x.
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引用本文的文献
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Comparison of oxyfedrine and atenolol in angina pectoris--a double-blind study.氧烯洛尔与阿替洛尔治疗心绞痛的比较——一项双盲研究。
Br J Clin Pharmacol. 1985 Oct;20(4):405-10. doi: 10.1111/j.1365-2125.1985.tb05085.x.
2
Effects of oxyfedrine on regional myocardial blood flow in patients with coronary artery disease.奥昔非君对冠心病患者局部心肌血流的影响。
Cardiovasc Drugs Ther. 1991 Dec;5(6):991-6. doi: 10.1007/BF00143526.
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Haemodynamic consequences of coronary heart disease with observations during anginal pain and on the effect of nitroglycerine.冠心病的血流动力学后果，包括心绞痛发作时的观察结果以及硝酸甘油的作用。
Br Heart J. 1958 Jul;20(3):302-10. doi: 10.1136/hrt.20.3.302.
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A controlled comparison of oxyfedrine, isosorbide dinitrate and placebo in the treatment of patients suffering attacks of angina pectoris.氧烯洛尔、硝酸异山梨酯与安慰剂治疗心绞痛发作患者的对照比较。
Br J Clin Pharmacol. 1980 Sep;10(3):211-5. doi: 10.1111/j.1365-2125.1980.tb01746.x.
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[The management of angina pectoris using Ildamen, a new coronary- and cardiac-active substance, in a double-blind study].[在一项双盲研究中使用新型冠状动脉及心脏活性物质伊达门治疗心绞痛]
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