氧烯洛尔与阿替洛尔治疗心绞痛的比较——一项双盲研究。
Comparison of oxyfedrine and atenolol in angina pectoris--a double-blind study.
作者信息
Fananapazir L, Bray C
出版信息
Br J Clin Pharmacol. 1985 Oct;20(4):405-10. doi: 10.1111/j.1365-2125.1985.tb05085.x.
Abstract
We have compared oxyfedrine 24 mg four times daily with atenolol 100 mg once daily in the relief of angina pectoris in a double-blind cross-over study; assessments were by diary cards and treadmill testing. Both oxyfedrine and atenolol reduced the frequency of angina by similar amounts and both produced similar improvements in treadmill performance. Side effects were infrequent and minor with both drugs. The model of action of oxyfedrine appears to be different from atenolol. Oxyfedrine allows the double product of systolic blood pressure X heart rate at peak exercise to be maintained at levels similar to those with placebo; the double product at peak exercise is significantly less with atenolol.
摘要
在一项双盲交叉研究中，我们将每日四次服用24毫克奥昔非君与每日一次服用100毫克阿替洛尔用于缓解心绞痛进行了比较；通过日记卡和跑步机测试进行评估。奥昔非君和阿替洛尔降低心绞痛发作频率的幅度相似，并且在跑步机测试表现上的改善也相似。两种药物的副作用都很少且轻微。奥昔非君的作用模式似乎与阿替洛尔不同。奥昔非君能使运动高峰时收缩压与心率的乘积维持在与服用安慰剂时相似的水平；而阿替洛尔使运动高峰时的该乘积显著降低。
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