Sequential changes in plasma lipoproteins and body fat composition during polyunsaturated fat feeding in man.

1. The early effects of a moderate polyunsaturated fat diet on the composition of circulating lipoproteins and adipose tissue fatty acids were measured in five healthy adults. 2. The fatty acid content and gross composition of the three major plasma lipoprotein fractions altered within 7 d of treatment. The response of depot fat was slower but did show a significant and progressive change after 14 d on the diet. 3. The efficiency of the moderate diet in changing the composition of the lipoproteins suggests that it should be equally effective in altering their metabolic handling.