Bershadsky A D, Tint I S, Gelfand V I, Rosenblat V A, Vasiliev J M, Gelfand I M
Cell Biol Int Rep. 1978 Jul;2(4):345-51. doi: 10.1016/0309-1651(78)90020-6.
Previous observations had shown that colcemid does not affect locomotion of epithelial cells. Nevertheless, cultured mouse kidney cells forming epithelial sheets were found to contain a well-developed microtubular system sensitive to colcemid. The orientation of microtubules in the epithelial cells was not correlated with the stable or active state of the cell edges. It is suggested that microtubular system of the epithelial cells forming coherent sheets, in contrast to that of individually moving fibroblasts, is not essential for stabilization of the lateral cell edges.
先前的观察表明秋水仙酰胺不影响上皮细胞的运动。然而，发现形成上皮片层的培养小鼠肾细胞含有对秋水仙酰胺敏感的发育良好的微管系统。上皮细胞中微管的取向与细胞边缘的稳定或活跃状态无关。这表明，与单个移动的成纤维细胞相比，形成连贯片层的上皮细胞的微管系统对于稳定细胞侧边缘并非必不可少。
