大鼠软脑膜小动脉对多巴胺的双相反应：对微循环的直接观察
Biphasic responsiveness of rat pial arterioles to dopamine: direct observations on the microcirculation.
作者信息
Altura B M, Gebrewold A, Lassoff S
出版信息
Br J Pharmacol. 1980 Aug;69(4):543-4. doi: 10.1111/j.1476-5381.1980.tb07900.x.
Abstract
The effects of local perivascular application of dopamine to rat pial arterioles. (20-40 micrometer i.d.) were examined in situ, at the microcirculatory level, by use of a high-resolution closed circuit television microscope recording system. Local application of very low, physiological doses (1 to 10 pg) of dopamine to pial arterioles of the anaesthetized rat induces vasodilatation, whereas higher doses induce vasoconstriction. The magnitudes of these biphasic responses obtained in male rats were not significantly different from those obtained in female animals. Our findings support the theory that local release of this neurotransmitter amine from perivascular cells in the brain may promote local increases in cerebral blood flow.
摘要
在大鼠软脑膜小动脉（内径20 - 40微米）局部血管周围应用多巴胺的效应，通过高分辨率闭路电视显微镜记录系统在微循环水平进行了原位研究。向麻醉大鼠的软脑膜小动脉局部应用极低的生理剂量（1至10皮克）多巴胺会引起血管舒张，而较高剂量则会引起血管收缩。在雄性大鼠中获得的这些双相反应的幅度与在雌性动物中获得的幅度没有显著差异。我们的研究结果支持这样一种理论，即这种神经递质胺从脑内血管周围细胞的局部释放可能促进局部脑血流量增加。
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