5-羟色氨酸的中枢作用对迷走神经反射性心动过缓的抑制作用。
Inhibition of reflex vagal bradycardia by a central action of 5-hydroxytryptophan.
作者信息
Tadepalli A S
出版信息
Br J Pharmacol. 1980 Aug;69(4):647-50. doi: 10.1111/j.1476-5381.1980.tb07916.x.
Abstract
1 Vagally mediated reflex bradycardia was elicited in spinal cats with intravenous pressor doses of noradrenaline. Administration of 5-hydroxytryptophan (1.5 and 3 mg total dose) into the fourth cerebral ventricle reduced the reflex bradycardia. 2 Inhibition of central amino acid decarboxylase with R044602 prevented the effects of 5-hydroxytryptophan. After intravenous administration of 5-hydroxytryptophan, vagal reflex bradycardia was not affected. 3 Results suggest that 5-hydroxytryptophan acts in the CNS to inhibit baroreceptor-mediated vagal reflex bradycardia and that action is mediated via conversion to 5-hydroxytryptamine.
摘要
- 静脉注射升压剂量的去甲肾上腺素可在脊髓猫中诱发迷走神经介导的反射性心动过缓。向第四脑室注射5-羟色氨酸（总剂量1.5和3毫克）可减轻反射性心动过缓。2. 用R044602抑制中枢氨基酸脱羧酶可阻止5-羟色氨酸的作用。静脉注射5-羟色氨酸后，迷走神经反射性心动过缓不受影响。3. 结果表明，5-羟色氨酸在中枢神经系统中起作用，抑制压力感受器介导的迷走神经反射性心动过缓，且该作用是通过转化为5-羟色胺介导的。
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