Saito D, Nixon D G, Vomacka R B, Olsson R A
Circ Res. 1980 Dec;47(6):875-82. doi: 10.1161/01.res.47.6.875.
Analysis of the relationships between cardiac oxygen usage (MVO2), cardiac muscle adenosine levels([Ado]), and coronary vascular resistance (R) in open-chest, anesthetized dogs tested the hypothesis that adenosine is a physiological regulator of coronary flow. Experiments using each dog as its own control showed that [Ado] varied directly with MVO2 as the latter changed spontaneously or in response to atrial pacing, paired pacing, aortic constriction, of beta-adrenergic blockade. In turn, R varied inversely with changes in [Ado]. Stimulating MVO2 with isoproterenol significantly increased the slope of the regression of [Ado] on MVO2 as well as of R-1 on [Ado]. The effect of beta-adrenergic stimulation on [Ado] is unexplained, but its effect on R-1 seems to reflect the combined effects of adenosine and direct beta-adrenergic coronary relaxation. These results support the hypothesis that adenosine mediates the coronary flow responses to changes in MVO2.
在开胸麻醉犬身上分析心脏氧耗量（MVO2）、心肌腺苷水平（[Ado]）和冠状血管阻力（R）之间的关系，检验了腺苷是冠脉血流的生理调节因子这一假说。以每只犬自身作为对照的实验表明，当MVO2自发变化或因心房起搏、成对起搏、主动脉缩窄或β-肾上腺素能阻滞而变化时，[Ado]与MVO2直接相关。相应地，R与[Ado]的变化呈负相关。用异丙肾上腺素刺激MVO2显著增加了[Ado]对MVO2以及R-1对[Ado]回归的斜率。β-肾上腺素能刺激对[Ado]的影响尚无法解释，但其对R-1的影响似乎反映了腺苷和直接的β-肾上腺素能冠脉舒张的联合作用。这些结果支持了腺苷介导冠脉血流对MVO2变化的反应这一假说。
