Srivastava S, Sarma Y S
Cytobios. 1980;28(110):95-102.
Effects of penicillin, streptomycin and tetracycline were seen on the karyology of a filamentous green alga, Oedogonium gunnii Wittr. Various nuclear and chromosomal aberrations such as, fragmentation of the chromosomes, extreme clumping and unequal groupings of the chromosomes, vacuolization of nuclei and nucleoli, and irregular anaphase chromatid breaks, were observed in the materials treated with 500 and 750 micrograms/ml streptomycin, and 250 and 500 micrograms/ml tetracycline, and which, however, were not seen with any of the concentrations of penicillin employed. With lower concentrations of the three antibiotics given continuously for longer duration, several aberrations were observed. The frequency of the aberrations did not seem to follow a regular pattern and varied with each antibiotic and the duration of treatment.
青霉素、链霉素和四环素对丝状绿藻冈氏鞘藻（Oedogonium gunnii Wittr.）的核型有影响。在用500和750微克/毫升链霉素以及250和500微克/毫升四环素处理的材料中，观察到了各种核和染色体畸变，如染色体断裂、染色体极度聚集和分组不均、细胞核和核仁空泡化以及后期染色单体不规则断裂，然而，在所使用的任何浓度的青霉素处理材料中均未观察到这些现象。用较低浓度的三种抗生素持续较长时间给药时，观察到了几种畸变。畸变的频率似乎没有遵循规律模式，且因每种抗生素和治疗持续时间而异。
