Miceli J N, Clay B, Fleischmann L E, Sarnaik A P, Aronow R, Done A K
Dev Pharmacol Ther. 1980;1(1):16-25.
In a patient severely poisoned with theophylline, saturation kinetics were demonstrated at serum concentrations > 35 micrograms/ml with subsequent conversion to first order kinetics (t 1/2 = 5.4 h). Peritoneal dialysis was used to enhance the drug's removal. The mean theophylline clearance was greater for dialysate (5.11 ml/min) than for urine (1.98 ml/min) or gastric fluid (0.32 ml/min). Urinary elimination occurred as a constant first order process (t 1/2 = 4.3 h). Peritoneal dialysis is a valuable early adjunct in the management of severe theophylline intoxication.
在一名严重茶碱中毒患者中，血清浓度>35微克/毫升时呈现饱和动力学，随后转变为一级动力学（半衰期=5.4小时）。采用腹膜透析以促进药物清除。透析液的平均茶碱清除率（5.11毫升/分钟）高于尿液（1.98毫升/分钟）或胃液（0.32毫升/分钟）。尿排泄为恒定的一级过程（半衰期=4.3小时）。腹膜透析是严重茶碱中毒治疗中有价值的早期辅助手段。
