Bendz R, Ström S, Olin C
Eur J Cardiol. 1980;12(1):25-39.
Serum catalytic concentrations of total creatine kinase (CK) and its more heart-specific isoenzyme CK-MB were studied in 25 consecutive patients subjected to isolated mitral valve replacement (Björk--Shiley prosthesis). Heart and skeletal muscle CK and CK-MB content was determined in 10 cases. The postoperative serum levels did not reflect differences in myocardial CK-MB content between patients. CK-MB as a percentage of total CK at peak serum CK-MB (16 +/- 1%) (mean +/- SEM) was of similar order as the percentage of CK-MB in the myocardium (papillary muscle 20.9 +/- 1.3%, right auricle 18.2 +/- 0.5%). A small proportion of CK-MB was present in all skeletal muscle samples examined (diaphragm 4.2 +/- 0.6%, rectus abdominis 0.4 +/- 0.1%), indicating that the total CK level should also be taken into account in attempts to determine the origin of a raised postoperative serum CK-MB activity. The degree of postoperative CK-MB elevation was related to the duration of operation and of aortic cross-clamping. Perioperative myocardial infarction occurred in one patient, and serum CK-MB kinetics in this patient, with a biphasic enzyme curve, differed from those in the other patients.
对连续25例接受单纯二尖瓣置换术（使用Björk-Shiley人工瓣膜）的患者，研究了血清中总肌酸激酶（CK）及其更具心脏特异性的同工酶CK-MB的催化浓度。测定了10例患者心脏和骨骼肌的CK及CK-MB含量。术后血清水平并未反映出患者之间心肌CK-MB含量的差异。血清CK-MB峰值时，CK-MB占总CK的百分比为（16±1%）（均值±标准误），与心肌中CK-MB的百分比（乳头肌20.9±1.3%，右心耳18.2±0.5%）处于相似水平。在所检查的所有骨骼肌样本中均存在一小部分CK-MB（膈肌4.2±0.6%，腹直肌0.4±0.1%），这表明在试图确定术后血清CK-MB活性升高的来源时，也应考虑总CK水平。术后CK-MB升高的程度与手术持续时间和主动脉阻断时间有关。1例患者发生围手术期心肌梗死，该患者血清CK-MB动力学呈双相酶曲线，与其他患者不同。
