Usui A, Abe T, Murase M, Tanaka M, Takeuchi E, Kato K
Nihon Kyobu Geka Gakkai Zasshi. 1989 Aug;37(8):1481-5.
By using highly sensitive enzyme immunoassay method recently developed, concentrations of the three forms of cytoplasmic creatine kinases (CK-BB, CK-MB and CK-MM) were determined in blood plasma samples serially taken from 18 patients, who received mitral valve replacement. Plasma CK-BB levels, that were 0.64 +/- 0.32 ng/ml at the beginning of anesthesia, increased sharply after reperfusion reaching peak levels (23.3 +/- 7.56 ng/ml) at 2 hours after reperfusion, and then decreased rapidly. The response of CK-BB in plasma was more rapid and sensitive than that of CK-BB or CK-MM. The CK-BB concentrations were significantly higher in coronary sinus samples than in arterial samples. These results suggest that the major portion of elevated plasma CK-BB levels at early phase after reperfusion were considered to be derived from the heart muscle.
采用最近开发的高灵敏度酶免疫测定法，对18例接受二尖瓣置换术患者连续采集的血浆样本中三种形式的细胞质肌酸激酶（CK-BB、CK-MB和CK-MM）浓度进行了测定。血浆CK-BB水平在麻醉开始时为0.64±0.32 ng/ml，再灌注后急剧升高，在再灌注后2小时达到峰值水平（23.3±7.56 ng/ml），然后迅速下降。血浆中CK-BB的反应比CK-MB或CK-MM更快、更敏感。冠状窦样本中的CK-BB浓度显著高于动脉样本。这些结果表明，再灌注后早期血浆CK-BB水平升高的主要部分被认为源自心肌。
