Proĭnova V A, Pershin G N, Shashkina L F, Nechushkina L V, Fedorova E A
Farmakol Toksikol. 1980 Jul-Aug;43(4):404-8.
The first generation progeny of rats received days 10-13 of pregnancy a new antiviral drug bonaphthon (400 mg/kg) which exerts a toxic effect on females. The progeny did not show postnatal death or reduction of the life span. Moreover, no impairment of muscle work capacity, basal metabolism, cardiovascular system, peripheral blood parameters, or changes in the function of organs and systems were recorded. Morphological and functional deviations in the liver of 2-month-old progeny were unstable and got repaired by 3 months of age.
在妊娠第10至13天给第一代大鼠后代注射一种新型抗病毒药物博纳芬（400毫克/千克），该药物对母鼠有中毒作用。后代未出现出生后死亡或寿命缩短的情况。此外，未记录到肌肉工作能力、基础代谢、心血管系统、外周血参数受损，或器官和系统功能发生变化。2个月大后代肝脏的形态和功能偏差不稳定，到3个月大时已恢复正常。
