Proĭnova V A, Shashkina L F, Nechushkina L V, Fedorova E A
Farmakol Toksikol. 1980 May-Jun;43(3):337-42.
The toxicity of the original drug bonaphthon was studied in pregnant and nonpregnant mice and rats given the drug orally and intraperitoneally. In a dose of 100 mg/kg bonaphthon had no toxic effect on pregnant rats after 4-time administration per os, while in a single dose of 400 mg/kg the drug elicited side effects such as congestion phenomena and inconsistent dystrophic changes in the parenchymal organs. Toxic effects in the liver were most pronounced when the drug was administered in the earlier periods of pregnancy.
对怀孕和未怀孕的小鼠及大鼠口服和腹腔注射原药波纳夫通，研究其毒性。以100毫克/千克的剂量对怀孕大鼠经口给药4次后，波纳夫通没有毒性作用，而单次剂量为400毫克/千克时，该药物引发了诸如充血现象以及实质器官中不一致的营养不良性变化等副作用。在怀孕早期给药时，肝脏的毒性作用最为明显。
