杜宾-约翰逊综合征中的胆盐转运
Bile salt transport in the Dubin-Johnson syndrome.
作者信息
Douglas J G, Beckett G J, Percy-Robb I W, Finlayson N D
出版信息
Gut. 1980 Oct;21(10):890-3. doi: 10.1136/gut.21.10.890.
Abstract
Serum bile salt measurements and intravenous clearance of glycocholate were performed in a woman with Dubin-Johnson syndrome. Fasting conjugated cholate concentration was raised and prolonged intravenous clearance of sodium glycocholate revealed a secondary rise in conjugated cholate concentration after two hours. The intravenous clearance of bromsulphthalein also showed a secondary rise. These findings support the proposal that Dubin-Johnson syndrome is not homogeneous and that in some patients a abnormality of bile salt clearance coexists with an abnormality of bilirubin nd bromsulphthalein clearance.
摘要
对一名患有杜宾-约翰逊综合征的女性进行了血清胆汁盐测量及甘氨胆酸盐静脉清除率测定。空腹结合胆酸盐浓度升高，甘氨胆酸钠静脉清除率延长，显示两小时后结合胆酸盐浓度出现二次升高。磺溴酞钠静脉清除率也出现二次升高。这些发现支持以下观点：杜宾-约翰逊综合征并非单一类型，在一些患者中，胆汁盐清除异常与胆红素及磺溴酞钠清除异常并存。
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