Beckett G J, Douglas J G, Nimmo I A, Finlayson N D, Percy-Robb I W
Clin Chim Acta. 1980 Jan 31;100(3):193-200. doi: 10.1016/0009-8981(80)90266-1.
The clearance of an injected dose of sodium glycocholate has been studied in a group of 23 control subjects who had no evidence of liver disease. A significant correlation was found between bile salt clearance and age. No significant difference was found between the bile salt clearance of male and female subjects. Data derived from a simple compartmental model indicated that decreased clearance of bile salt with age was not specifically related to degenerative changes in hepatocellular integrity, hepatic uptake of bile salts or bile flow.
在一组23名无肝病证据的对照受试者中，对注射剂量的甘氨胆酸钠的清除情况进行了研究。发现胆盐清除率与年龄之间存在显著相关性。男性和女性受试者的胆盐清除率没有显著差异。来自简单房室模型的数据表明，随着年龄增长胆盐清除率降低并非特别与肝细胞完整性的退行性变化、肝脏对胆盐的摄取或胆汁流动有关。
