Alberman E, Pharoah P, Chamberlain G, Roman E, Evans S
Int J Epidemiol. 1980 Sep;9(3):207-13. doi: 10.1093/ije/9.3.207.
The use of oral contraception by women doctors on the Medical Register for England and Wales in 1975 was studied and related to the outcome of their pregnancies. Nearly two thirds had used oral contraception at some time, but less than one third of their pregnancies had followed its use. Users tended to be younger at the time of the survey and to smoke in pregnancy more often. After allowing for these associations a poor outcome was just slightly more common in pregnancies occurring after OC use, particularly in conceptions occurring within a month or after a year of cessation. In contrast conceptions occurring in the 2nd or 3rd month after cessation had an unusually favourable outcome. It therefore seems likely that at least some of this weak association between oral contraception and poor outcome may be explained by factors that determine the length of time it takes to conceive. Overall it seems that any real risk to pregnancies conceived after cessation of oral contraception must be very small and outweighed by the undoubted advantages of its use.
对1975年在英格兰和威尔士医学注册名录上的女医生口服避孕药的使用情况进行了研究,并将其与她们的妊娠结局相关联。近三分之二的人曾在某些时候使用过口服避孕药,但只有不到三分之一的妊娠是在使用避孕药之后发生的。使用者在调查时往往更年轻,孕期吸烟的情况也更常见。在考虑到这些关联因素后,口服避孕药使用后发生的妊娠结局不良情况只是略为常见一些,尤其是在停药后一个月内或停药一年后怀孕的情况。相比之下,停药后第二或第三个月怀孕的结局异常良好。因此,口服避孕药与不良结局之间这种微弱关联,似乎至少有一部分可以由决定受孕所需时间的因素来解释。总体而言,口服避孕药停药后怀孕面临的任何实际风险似乎都非常小,且其使用带来的无疑优势超过了这些风险。