Hedrick P W, McDonald J F
Heredity (Edinb). 1980 Aug;45(1):83-97. doi: 10.1038/hdy.1980.52.
There is increasing support for the notion that changes in regulatory loci have played a major role in eukaryotic evolution. Assuming a model of genetic regulation based upon presently accepted views of the organisation of the eukaryotic genome and basic models of evolutionary genetics, one can provide a context for speculation about the advantages and disadvantages of adaptation via regulatory genes. As additional information is obtained on particular regulatory systems, the evolutionary genetic model can be modified and expanded.
越来越多的人支持这样一种观点，即调控基因座的变化在真核生物进化中起了主要作用。假设基于目前关于真核生物基因组组织的公认观点和进化遗传学的基本模型建立一个遗传调控模型，就可以为推测通过调控基因进行适应的优缺点提供一个背景。随着关于特定调控系统的更多信息的获得，进化遗传模型可以得到修改和扩展。
