Wilson I D, McClain C J, Erlandsen S L
Histochem J. 1980 Jul;12(4):457-71. doi: 10.1007/BF01011961.
Morphological abnormalities in Paneth cells occur in patients with acrodermatitis enteropathica, a hereditary disease associated with zinc deficiency; furthermore, rat Paneth cells contain large amounts of zinc. This study was conducted to assess the effect of severe zinc deficiency in Sprague-Dawley rats on various parameters of Paneth cells. Morphology at both the light microscopical and ultrastructural levels, Paneth cell numbers per crypt and the intracellular distribution of lysozyme were not altered by zinc deficiency. A weak correlation (r = +0.38, P = 0.05) was noted between ileal zinc concentration and numbers of IgA-containing Paneth cells per crypt. These findings indicate that the morphological abnormalities noted in human Paneth cells in patients with acrodermatitis enteropathica cannot be reproduced by experimental severe zinc deficiency in rats. Furthermore, these generally negative findings suggest that the severe diarrhoea often associated with zinc deficiency is not attributable to abnormalities induced in Paneth cells by zinc deficiency.
肠病性肢端皮炎患者的潘氏细胞会出现形态学异常，这是一种与锌缺乏相关的遗传性疾病；此外，大鼠的潘氏细胞含有大量锌。本研究旨在评估严重锌缺乏对斯普拉格-道利大鼠潘氏细胞各项参数的影响。光镜和超微结构水平的形态、每个隐窝的潘氏细胞数量以及溶菌酶的细胞内分布均未因锌缺乏而改变。观察到回肠锌浓度与每个隐窝含IgA的潘氏细胞数量之间存在弱相关性（r = +0.38，P = 0.05）。这些发现表明，实验性大鼠严重锌缺乏无法重现肠病性肢端皮炎患者人类潘氏细胞中所观察到的形态学异常。此外，这些普遍的阴性结果表明，通常与锌缺乏相关的严重腹泻并非归因于锌缺乏引起的潘氏细胞异常。
